News on new antiviral drugs, vaccines, diagnostic tests, viral outbreaks, novel viruses and milestone discoveries are curated by expert virologists. In this study, a sindbis virus replicase‐based DNA vaccine, pSinCMV‐Vac‐MEG990, encoding a multivalent epitope gene (representing tandemly linked VP1 C‐terminal halves of three foot‐and‐mouth disease virus (FMDV) serotypes) was constructed. 2019 Mar 8;7(1):29. doi: 10.3390/vaccines7010029. Epub 2007 Oct 31. Further, immune responses induced with replicon-based rabies DNA vaccine (pAlpha-Rab-G) was compared with conventional rabies DNA vaccine and commercial cell culture vaccine (Rabipur) in intramuscularly injected mice. SYNONYM OR CROSS REFERENCE: Epidemic polyarthritis and rash, Sindbis virus disease, SIN, SINV, Ockelbo disease or August-September disease in Sweden Footnote 3, Pogosta disease in Finland, and Karelian fever in Russia1-6. The clinical disease caused by SINV infection is known as Pogosta diseas… A Microneedle Patch for Measles and Rubella Vaccination Is Immunogenic and Protective in Infant Rhesus Macaques. NAME: Sindbis virus (SINV) Footnote 1-4. (C) IFN-γ-secreting T cells measured in PBL. Sindbis virus is related to Chikungunya alphavirus. 1992 Feb;184(2-3):180-92. doi: 10.1016/S0171-2985(11)80474-2. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. A sindbis virus replicon-based DNA vaccine encoding the rabies virus glycoprotein elicits immune responses and complete protection in mice from lethal challenge. COVID-19 is an emerging, rapidly evolving situation. Alphavirus replicase genes are expressed in addition to the vaccine insert. (A)…, NLM Sindbis Virus. These results demonstrate that replicon-based rabies DNA vaccine is effective in inducing both humoral and cellular immune responses and can be considered as effective vaccine against rabies. Rift Valley fever virus (RVFV) is a mosquito-transmitted bunyavirus (genus Phlebovirus) associated with severe disease in livestock and fatal encephalitis or haemorrhagic fever in a proportion of infected humans. 2007 Dec;82(6):672-85. doi: 10.1038/sj.clpt.6100420. These vaccines are self-replicating and self-limiting and may be administered as either RNA or DNA, which is then transcribed into RNA replicons in transfected cells or in vivo ( 4 , 18 ). By continuing you agree to the use of cookies. The first human cases were described in Uganda in 1961, South Africa in 1963, and Australia in 1967. Webster DE, Thomas MC, Huang Z, Wesselingh SL. Please enable it to take advantage of the complete set of features! The virus was first isolated in 1952 in Cairo, Egypt. Attenuated Salmonella enterica serovar Typhi and Shigella flexneri 2a strains mucosally deliver DNA vaccines encoding measles virus hemagglutinin, inducing specific immune responses and protection in cotton rats. Vaccine 26 : 6592 – 6601 . Neutralizing antibodies, mucosal and systemic antibody-secreting cells, memory B cells, and gamma interferon-secreting T cells developed after priming and increased after boosting. The mice immunized with replicon-based rabies DNA vaccine induced humoral and cell mediated immune responses better than conventional rabies DNA vaccine however, comparable to Rabipur vaccine. Accueil > Les actualités. Foot‐and‐mouth disease (FMD) is still a perennial global menace affecting livestock health and production. See this image and copyright information in PMC. RNA replicon vaccines may be derived from alphavirus vectors, such as Sindbis virus , Semliki Forest virus (3, 4), or Venezuelan equine encephalitis virus vectors. The TC-83 strain also retains residual murine virulence and is lethal for suckling mice after intracerebral (i.c.) 2003 May;77(9):5209-17. doi: 10.1128/jvi.77.9.5209-5217.2003. Data represent mean frequencies of IgG ASC or IFN-γ SFC per 1 × 10. Vaccination against acute respiratory virus infections and measles in man. (A) Cotton rats were primed with two doses (100 μg/each) of pMSIN-H, pMSINH-FdU, or pSINCP given intramuscularly on days 0 and 28. Pulmonary cytokine gene expression in cotton rats after vaccination and MV challenge. Both chimeric viruses replicated efficiently in mammalian … This site needs JavaScript to work properly. 13, No. SINV causes sindbis fever in humans and the symptoms include arthralgia, rash and malaise. It is imperative to figure out new ways to curb this disease. 9 Enhancement of dendritic cell-based vaccine potency by targeting antigen to endosomal/lysosomal compartments On challenge with rabies virus CVS strain, replicon-based rabies DNA vaccine conferred complete protection similar to Rabipur. J Virol. Le virus Sindbis est un arbovirus, il se transmet via les vertébrés, comme les oiseaux, aux invertébrés comme les moustiques. Pasetti MF, Barry EM, Losonsky G, Singh M, Medina-Moreno SM, Polo JM, Ulmer J, Robinson H, Sztein MB, Levine MM. Long-term efficacy of a hepatitis E vaccine, N Engl J Med, 2015;372:914-922 ↑ (en) Barnaud E, Rogée S, Garry P, Rose N, Pavio N ... à une infection provoquée par le virus de l'hépatite E (VHE). Virus Sindbis Coupe proportionnelle dun virus Sindbis Espèce Virus Sindbis - auteur incomplet -, date à préciser Le virus...Le virus Sindbis est un arbovirus, il se transmet via les vertébrés, comme les oiseaux, aux invertébrés comme les moustiques. pMSIN-H priming conferred 100% protection against pulmonary measles, whereas pMSINH-FdU protected only in conjunction with the live measles virus vaccine boost. CHARACTERISTICS: Of the genus Alphavirus, and a member of the Togaviridae family. Copyright © 2021 Elsevier B.V. or its licensors or contributors. Néanmoins, certains symptômes peuvent être observés, associant de la fièvre et des douleurs dans … Heterologous prime-boost strategy to immunize very young infants against measles: pre-clinical studies in rhesus macaques. USA.gov. 2006 May 1;176(9):5671-81. doi: 10.4049/jimmunol.176.9.5671. (A) Frequency of MV-specific IgG-secreting cells in the lung and PBL. Sindbis virus replicon particles encoding calreticulin linked to a tumor antigen generate long-term tumor-specific immunity 28 April 2006 | Cancer Gene Therapy, Vol. … 2005 Mar 7;23(15):1859-65. doi: 10.1016/j.vaccine.2004.11.018. The transfected … Would you like email updates of new search results? The self-amplification of RNA transcripts and translation efficiency of rabies G was analyzed in pAlpha-Rab-G-transfected mammalian cells using RT-PCR, SDS-PAGE and Western blot analysis. 1. Towards this goal, Sindbis virus … Sindbis fever is most common in Southern Africa, East Africa, Egypt, Palestine, the Philippines and parts of Australia. (B) Relative expression of IL-4 and IFN-γ. A Sindbis virus replicon-based DNA vaccine encoding the rabies virus glycoprotein elicits immune responses and complete protection in mice from lethal challenge. Data represent mean mRNA cytokine expression from four animals ± standard errors of the means. 2019 Jul 27;11(8):688. doi: 10.3390/v11080688. One vaccine candidate contained structural protein genes from a typical North American EEEV strain, while the other had structural proteins from a naturally attenuated Brazilian isolate. Neutralizing antibodies, mucosal and systemic antibody-secreting cells, memory B cells, and gamma interferon-secreting T … Sindbis virus is a member of the alphavirus family that has been studied extensively for use as a treatment for many different kinds of cancer. (A)…, Pulmonary cytokine gene expression in cotton rats after vaccination and MV challenge. The virus was subsequently acknowledged as the causative agent of a rash-arthritis syndrome. Highlighted news include trending and most cited scientific articles in these fields with links to the original publications. Generation of a More Immunogenic Measles Vaccine by Increasing Its Hemagglutinin Expression.  |  Sujet : . Des sérotypes (différentes par moins de 17 % en séquence nucléotidique) comprennent Babanki, Kyzylagach et Ockelbo virus. We developed chimeric Sindbis (SINV)/Eastern equine encephalitis (EEEV) viruses and investigated their potential for use as live virus vaccines against EEEV. The development of a plant-based vaccine for measles. Virus World provides a daily blog of the latest news in the Virology field and the COVID-19 pandemic. NIH The non-segmented genome consists of a singl… Ce vaccin a induit une immunité protectrice contre ces six agents infectieux, notamment vis-à-vis du virus grippal H1N1, du parasite de la toxoplasmose (Toxoplasma gondii) et du virus Ebola. Isolation was by inoculation of triturated mosquitoes into 3-day-old mice. We use cookies to help provide and enhance our service and tailor content and ads. Sindbis virus (SINV) is a member of the Togaviridae family, in the Alphavirus genus. Measles remains an important cause of pediatric morbidity and mortality in developing countries, especially among infants who are too young to receive the current licensed live attenuated measles vaccine. 2018 Jun 5;218(1):124-132. doi: 10.1093/infdis/jiy139. (B) MV-specific memory B cells measured in the BM. This vaccine presents several problems, including adverse, sometimes severe reactions in many human vaccinees. In vitro transfection studies in BHK-21 cells revealed that the construct was able to express FMDV-specific antigen but does not overproduce the antigen. Viruses. Vaccine. J Immunol. Print 2016 Jun 1. The genome of this … Pasetti MF, Resendiz-Albor A, Ramirez K, Stout R, Papania M, Adams RJ, Polack FP, Ward BJ, Burt D, Chabot S, Ulmer J, Barry EM, Levine MM. Viruses. (D) Protection against measles virus respiratory challenge. Efficacy was also reported for Sindbis virus-based DNA vaccines (Saxena et al., 2008), which, unlike conventional DNA vaccine, generate self-replicate RNA transcripts and thus achieve superior protein-expression levels. Both aspects are important requirements for efficient and safe DNA-based immunotherapy of type I allergies. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error, PRN titers elicited by Sindbis virus-based MV DNA vaccines administered alone as a “prime” or followed by a subsequent boost with the live attenuated EZ measles vaccine in a heterologous “prime-boost” regimen. Probing Morbillivirus Antisera Neutralization Using Functional Chimerism between Measles Virus and Canine Distemper Virus Envelope Glycoproteins. One vaccine candidate contained structural protein genes from a typical North American EEEV strain, while the other had structural proteins from a naturally attenuated Brazilian isolate. The virus infects a cell and shuts down production of endogenous protein for the host cell, thereby increasing expression of viral proteins. The transfected cells also showed induction of apoptosis which is an important event in the enhancement of immune responses. We developed chimeric Sindbis (SINV)/eastern equine encephalitis (EEEV) viruses and investigated their potential for use as live virus vaccines against EEEV. Consequently, the expression profile of sindbis virus is very rapid onset, extremely high expression, and then rapid … Virions are spherical to pleomorphic (70 nm in diameter), consisting of an envelope and nucleocapsid. (A) Cytokine mRNA expression in lung homogenates measured by reverse transcription-PCR. 2014 Jun 16;6(6):2392-415. doi: 10.3390/v6062392. Sindbis (SIN) virus was first isolated in 1952 from a group of Culex univittatus mosquitoes captured in a light trap in the Sindbis health district 30 km north of Cairo, Egypt. Unlike conventional DNA vaccinations alphavirus vectors kill transfected cells and are only transiently expressed. Amplified products were quantified by Southern blotting and normalized to the level of β-actin (housekeeping gene). Recherche : Cynomolgus macaques were either sham-vaccinated, or … 2016 May 12;90(11):5270-5279. doi: 10.1128/JVI.00348-16. or subcutaneous (s.c.) inoculation. Highlighted news include trending and most cited scientific articles in these fields with links to the original publications. The virus is transmitted by mosquitoes (Culex spp.) Vaccines (Basel). Enhancement of Sindbis Virus Self-Replicating RNA Vaccine Potency by Targeting Antigen to Endosomal/Lysosomal Compartments Virus World provides a daily blog of the latest news in the Virology field and the COVID-19 pandemic. Le virus Sindbis, proche de celui à l'origine du chikungunya, est transmis par un moustique.La plupart du temps, une contamination par le virus Sindbis passe inaperçue. Virus Sindbis: Le type espèces de ALPHAVIRUS normalement transmis à oiseaux par Culex moustiques en Égypte, Afrique du Sud, en Inde, Malaisie, les Philippines et l'Australie.Il peut être associée à une fièvre chez les humains. News on new antiviral drugs, vaccines, diagnostic tests, viral outbreaks, novel viruses and milestone discoveries are curated by expert virologists. Safety of Sindbis Virus The low level of pathogenicity of Sindbis virus in humans has allowed it to be classified as a Biosafety Level-2 (BL-2) agent by the NIH Recombinant DNA Advisory Committee. Sindbis Virus Replicase-based DNA Vaccine Construct Encoding FMDV-specific Multivalent Epitope Gene: Studies on its Immune Responses in Guinea Pigs Sindbis virus was first isolated from Culexmosquitoes in 1952 in the Nile river delta in Egypt. The Sindbis virus and Semliki Forest virus have been used to build recombinant alphavirus replicons. Schultz-Cherry , S , Dybing , JK , Davis , NL , Williamson , C , Suarez , DL , Johnston , … PRN titers elicited by Sindbis virus-based MV DNA vaccines administered alone as a…, Vaccine-induced B- and T-cell responses and protection against respiratory measles virus challenge. Clipboard, Search History, and several other advanced features are temporarily unavailable. The self-amplification of RNA transcripts and translation efficiency of rabies G was analyzed in pAlpha-Rab-G-transfected mammalian cells using RT-PCR, SDS-PAGE and Western blot analysis. Sindbis virus (SINV) is an enveloped RNA virus of the genus Alphavirus in the virus family Togaviridae. https://doi.org/10.1016/j.vaccine.2008.09.055. Two chimeric vaccine candidates were constructed using a cDNA clone with a Sindbis virus (SINV) backbone and structural protein genes from either a North (SIN/NAEEEV) or South American (SIN/SAEEEV) strain of EEEV. Before synthesizing any constructs, experiments should be cleared through your institutional biosafety committee. The vaccine candidates were tested in a nonhuman primate (NHP) model of eastern equine encephalitis (EEE). Publication types Research Support, Non-U.S. Gov't Objective: A Sindbis virus replicon-based DNA vaccine encoding the major timothy grass pollen allergen Phl p 5 was evaluated for its antiallergic potential compared with a conventional DNA vaccine in a BALB/c mouse model of allergy.  |  Clin Pharmacol Ther. (E) Lung viral replication versus PRN antibody titers at the time of challenge. A sindbis virus replicon-based DNA vaccine encoding rabies virus glycoprotein (G) was developed by subcloning rabies G gene into a sindbis virus replicon-based vaccine vector (pAlpha). Capozzo AV, Ramírez K, Polo JM, Ulmer J, Barry EM, Levine MM, Pasetti MF. Immunobiology. J Virol. The injection of a pcDNA3.1-based DNA vaccine encoding for FMDV P1-2A3C3D and GM-CSF proteins had previously been shown to induce the production of neutralizing antibodies against FMDV and partially protect swine against an experimental challenge. ... Ce virus fut isolé pour la première fois en 1952 au Caire, en Égypte. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Joyce JC, Carroll TD, Collins ML, Chen MH, Fritts L, Dutra JC, Rourke TL, Goodson JL, McChesney MB, Prausnitz MR, Rota PA. J Infect Dis. A sindbis virus replicon-based DNA vaccine encoding rabies virus glycoprotein (G) was developed by subcloning rabies G gene into a sindbis virus replicon-based vaccine vector (pAlpha). Neonatal immunization with a Sindbis virus-DNA measles vaccine induces adult-like neutralizing antibodies and cell-mediated immunity in the presence of maternal antibodies. Pour être mieux vacciné, sans défaut ni excès. We developed two Sindbis virus DNA vaccines encoding the measles virus hemagglutinin (pMSIN-H) and fusion proteins (pMSINH-FdU) and examined their immunogenicities and protective efficacies when administered alone or followed by the live measles virus vaccine in cotton rats. Copyright © 2008 Elsevier Ltd. All rights reserved. Although live attenuated and inactivated vaccines have been used in livestock, and on a limited scale in humans, there is a need for improved anti-RVFV vaccines. HHS (B) DNA priming was followed by a single boost with the EZ measles vaccine (0.5 ml, ∼5 × 10, Vaccine-induced B- and T-cell responses and protection against respiratory measles virus challenge. To overcome these negative effects, we developed a recombinant, chimeric Sindbis/VEE virus (SIN-83) that is more highly attenuated. Single-shot injection of 13 microg of each PrV glycoprotein encoding Sindbis virus-derived plasmid is able to effectively protect pigs from PrV infection. One month after the last immunization, lung, PBL, and BM were harvested from four animals in each group; the remaining animals were challenged with wild-type MV. Cotton rats were immunized as described in the legend to Fig.  |  In this study, a sindbis virus replicase-based DNA vaccine, pSinCMV-Vac-MEG990, encoding a multivalent epitope gene (representing tandemly linked VP1 C-terminal halves of three foot-and-mouth disease virus (FMDV) serotypes) was constructed. 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