The crystallinity and β′ crystal polymorph, which contribute to the hardness of fat-based food products, were quantitatively visualized in a model fat (porcine adipose tissue) by analyzing several key Raman bands. Poly(3-hexyllthiophene) (P3HT) with high crystallinity was prepared by controlling the solvent evaporation rate together with the aid of chloroform vapor annealing. The effect of protein concentration, in the range of 0–26 mg/mL for two Fc-fusion proteins, on the crystallinity and polymorphism of mannitol and sodium chloride in a lyophilized model formulation was examined. You are currently offline. This site needs JavaScript to work properly. The conformation of polymer chains and the mode of packing are used in the classification of polymorphism. THIS paper shows a universal correlation of the non-crystalline state with polymorphism in elemental solids. This means that apart from the molecular structure of the active ingredient, solid-state properties significantly influence the performance of the final product. Investigation of surface-modified solid lipid nanocontainers formulated with a heterolipid-templated homolipid. Presence of an undesired polymorph could lead to a reduction in therapeutic benefit, due to changes in API solubility, and may even cause an adverse effect to the patient. Carbon: diamond in cubic (tetrahedral lattice arrangement) graphite in sheets of a hexagonal lattice. Development of a Multifunctional Bioerodible Nanocomposite Containing Metronidazole and Curcumin to Apply on L-PRF Clot to Promote Tissue Regeneration in Dentistry. Michiyo Motoyama *, Koichi Chikuni, Takumi Narita, Katsuhiro Aikawa, and ; Keisuke Sasaki; View Author Information . Similar phenomenon in compounds, scientifically referred to as polymorphism. Polymorphic behaviour of Compritol®888 ATO as bulk lipid and as SLN and NLC, The influence of lipid characteristics on the formation, in vitro release, and in vivo absorption of protein-loaded SLN prepared by the double emulsion process. 2. NIH Andreani T, Dias-Ferreira J, Fangueiro JF, Souza ALR, Kiill CP, Gremião MPD, García ML, Silva AM, Souto EB. To solve the open question, a reliable calculation method for crystallinity, crystal forms, and composition in neat PLA and PLA composites was developed on the basis of temperature-dependent synchrotron wide-angle X-ray diffraction results. 2011 Aug 1;86(1):125-30. doi: 10.1016/j.colsurfb.2011.03.029. These properties make TPS potentially an ideal tool to investigate crystallinity and polymorphism. Crystallization of polymers is a process associated with partial alignment of their molecular chains. THIS paper shows a universal correlation of the non-crystalline state with polymorphism in elemental solids. Different crystalline forms are called polymorphs. Here successful utilization of polymorph having significant greater thermodynamic activity (solubility)may provide good therapeutic blood level from otherwise inactive drugs. Supercritical fluid precipitation of ketoprofen in novel structured lipid carriers for enhanced mucosal delivery--a comparison with solid lipid particles.  |  Polymorphism: Elements can exist in two or more different forms, known as allotropes of that element .eg. Proper monitoring by appropriate physicochemical and/or processing conditions is therefore mandatory. Wolska E, Sznitowska M, Krzemińska K, Ferreira Monteiro M. Pharmaceutics. The lipids were analyzed by Differential Scanning Calorimetry (DSC), Wide Angle X-ray Diffraction (WAXD), Polarized Light Microscopy (PLM) and hydrophilic-lipophilic balance (HLB) in combination with selected surfactants to determine the best solid-to-liquid ratio. Introduction: Solid-State Development The majority of drugs are administered as solids. CRYSTALLINITY & PARTICLE SIZE,PARTICLE SIZE DISTRIBUTION (AS A PART OF PREFORMULATION STUDIES) CRYSTALLINITY CONTENTS:- 1. Polyhydroxy surfactants for the formulation of lipid nanoparticles (SLN and NLC): effects on size, physical stability and particle matrix structure. Semantic Scholar is a free, AI-powered research tool for scientific literature, based at the Allen Institute for AI. Based on the results obtained by DSC and WAXD, the selected qualitative and quantitative composition contributed for the production of stable nanoparticles, since the melting and the tempering processes provided important information on the thermodynamic stability of solid lipid matrices. Polymorphism, crystallinity and hydrophilic-lipophilic balance of stearic acid and stearic acid-capric/caprylic triglyceride matrices for production of stable nanoparticles. A higher resolution is one way of resolving this. Polymorphism is defined as the ability of a chemical compound to occur in more than one crystal structures. Analytical Techniques for the Assessment of Drug-Lipid Interactions and the Active Substance Distribution in Liquid Dispersions of Solid Lipid Microparticles (SLM) Produced de novo and Reconstituted from Spray-Dried Powders. DOI: 10.36959/758/540 Corpus ID: 211138179. Sigma-Aldrich prepared a sorbitol sample (mass: 3.81 mg) in a Concavus crucible and measured with the DSC 204 F1 Nevio. Foods. fusion proteins, on the crystallinity and polymorphism of mannitol and sodium chloride in a lyophilized model formulation was examined. In Situ Raman Spectrometric Analysis of Crystallinity and Crystal Polymorphism of Fat in Porcine Adipose Tissue. 2. Eg novobiocin . Thus, the selection of lipids requires the evaluation of their polymorphism, and crystallinity miscibility and physicochemical structure. Influence of emulsifiers on the crystallization of solid lipid nanoparticles. 1. Polymorphism, crystallinity and hydrophilic-lipophilic balance of stearic acid and stearic acid-capric/caprylic triglyceride matrices for production of stable nanoparticles . Clipboard, Search History, and several other advanced features are temporarily unavailable. Introduction. Bisoprolol fumarate is a beta blocker-type drug substance which has been well known for several decades. Request PDF | Polymorphism, Crystallinity and Hydrophilic-Lipophilic Balance (HLB) of Cetearyl Alcohol and Cetyl Alcohol as Raw Materials for Solid Lipid Nanoparticles (SLN) | … The lines that connect the data points serve as guides to the eye. Solubility, polymorphism, crystallinity, and crystal habit of acetaminophen and racemic (±)-ibuprofen were determined by initial screening of 23 solvents for scale-up. It can be classifies as Internal structures (cubic, tetragonal, hexagonal, rhombic, etc. Institute of Livestock and Grassland Science, National Agricultural Research Organization (NARO), Ibaraki 305-0901, Japan *Phone: +81 29 838 8690. In this study four drugs with different solid-state properties were analyzed using TPS and levels of polymorphism and crystallinity were quantified. Selection and characterization of suitable lipid excipients for use in the manufacture of didanosine-loaded solid lipid nanoparticles and nanostructured lipid carriers. The results indicate that the polymorphism and crystallinity of IMC encapsulated in IMC-loaded PLA microspheres was dependent on the type of protective colloid and PLA used. Polymorphism in retrograded starches wa … COVID-19 is an emerging, rapidly evolving situation. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Polymorphism: an evaluation of the potential risk to the quality of drug products from the Farmácia Popular Rede Própria 3 Challenges for the Pharmaceutical Industry One of the first reports concerning the influence of polymorphism on drugs dates back to 1967 (Aguiar et al., 1967). Molecules in a crystal lattice are held by weak bonds such as van der Waals forces or hydrogen bonds. ), Solid habits (platy, needle, tabular, prismatic, bladed, etc. Severino P(1), Pinho SC, Souto EB, Santana MH. Characterization of relevant polymorph prop-erties provides the understanding needed for 2020 Mar 26;21(7):2285. doi: 10.3390/ijms21072285. 2020 May 3;6(5):e03831. Crystallization affects optical, … The observed Raman spectra, which were almost completely due to fat, showed clear dependence on the refrigeration time and carcass temperature. Int J Pharm. X-ray diffraction is a common technique that determine a sample's composition or crystalline structure. Alert. Medicines/quality control. Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility. INTRODUCTION Cellulose is both the world’s most abundant natural material and the world’s oldest known biomaterial (Griffith, 2008). 2007 Jul 10;59(6):379-402. doi: 10.1016/j.addr.2007.04.013. Polymorphism and orientation development in melt spinning, drawing, and annealing of nylon‐6 filaments. polymorphism and crystallinity are influenced by temperature change so DSC is indispensable in un-derstanding the thermophysical properties of phar-maceuticals. Some features of the site may not work correctly. Polymorphism in materials science is the ability of a solid material to exist in more than one form or crystal structure. Polymorphism and crystallinity of the lipid raw-materials influence the drug's encapsulation efficiency in SLN, as well as the drug retention in the lipid matrix during storage time [ 18 ]. Particular polymorphic forms can be obtained by varying crystallization conditions. Polymorphism The commercial applications of celluloses are numer-ous: as an energy source, a source for clothing and fabrics, NLM Within this, the polymorphism and crystallinity of the Active Pharmaceutical Ingredients (APIs) and excipients present within a product formulation are crucial. Polymorphism must be controlled to prevent possible ineffective therapy and/or improper dosage. Int J Pharm. Polymorphism, crystallinity and hydrophilic-lipophilic balance of stearic acid and stearic acid-capric/caprylic triglyceride matrices for production of stable nanoparticles. Polymorphs are of 2 types 1. Crystallinity and polymorphism: The structure of a solid compound refers as crystallinity and these structures disappear in the liquid and vapor states. In this study four drugs with different solid‐state properties were analyzed using TPS and levels of polymorphism and crystallinity were quantified. 2011;28(1):74-81. doi: 10.3109/02652048.2010.529948. Solubility, polymorphism, crystallinity, and crystal habit of acetaminophen and racemic (±)-ibuprofen were determined by initial screening of 23 solvents for scale-up. Crystallinity of Dynasan®114 and Dynasan®118 matrices for the production of stable Miglyol®-loaded nanoparticles. The shady parts correspond to the annealing conditions that result in the optimum ferroelectric performance. How to Measure. XRPD serves as an important tool for controlling purity, crystallinity and polymorphism for API and excipients. Polymorphism, crystallinity and hydrophilic-lipophilic balance of stearic acid and stearic acid-capric/caprylic triglyceride matrices for production of stable nanoparticles There is an increasing interest in lipid nanoparticles because of their suitability for …  |   |  polymorphism and crystallinity are influenced by temperature change so DSC is indispensable in un-derstanding the thermophysical properties of phar-maceuticals. The degree of crystallinity of drug substances has marked effect on its hardness, density, transparency and diffusion. A higher resolution is one way of resolving this. Crystallinity and polymorphism play an important role in, e.g., the solubility and stability of freeze-dried products. Crystallinity and polymorphism of 6‐polyamide. Please enable it to take advantage of the complete set of features! 1 LCPO - Laboratoire de Chimie des Polymères Organiques . By Patricia SEVERINO, Samantha C. PINHO, Eliana B. SOUTO and Maria H. A. SANTANA. These properties make TPS potentially an ideal tool to investigate crystallinity and polymorphism. Annamaria Fichera. The polymorphism of isotactic polypropylene (iPP) in combination with the strong response of this polymer to nucleation can be utilized for expanding the application range of this versatile polymer. 2010 Sep-Oct;17(7):467-89. doi: 10.3109/10717544.2010.483257. As the sample becomes crystalline from an initially amorphous compound, the Raman peaks become sharper and more intense. This influences both the choice of the delivery system and activity as determined by the rate of delivery. Thus, it becomes even more relevant the physicochemical characterization of lipid materials with respect to their polymorphism, lipid miscibility and stability, as well as the assessment of the effect of surfactant on the type and structure of these nanoparticles. 2007 Apr 4;334(1-2):179-89. doi: 10.1016/j.ijpharm.2006.10.032. Carbon: diamond in cubic (tetrahedral lattice arrangement) graphite in sheets of a hexagonal lattice. View 3 excerpts, references background ; Save. Uniterms: Polymorphism. The best performing structure exhibits a high degree of crystallinity, a preferential orientation of the crystallites with the polymer chains parallel to the substrate and the occurrence of three ferroelectric phases. Crystallinity and polymorphism. In this research, for the first time, dual retrogradation-annealing modification was applied to three rice starches with 22.7%, 9.8% and 0.3% apparent amylose content (AAC). Heliyon. For large production of lipid nanoparticles, the control of polymorphism is a demand due to its influence on the encapsulation efficiency and on the drug expulsion during storage. Polymorphism, crystallinity and hydrophilic-lipophilic balance of stearic acid and stearic acid-capric/caprylic triglyceride matrices for production of stable nanoparticles. P. Severino, S. C. Pinho, E. Souto, M. Santana; Chemistry, Medicine; Colloids and surfaces. Materials that have the same chemical formula but different states of the solid form are known as polymorphs. Key words: Reference materials, polymorphism, crystallinity, cellulose, PDF I.

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